:root{--color-primary: #2563eb;--color-bg: #f8fafc;--color-card: #ffffff;--color-text: #1e293b;--color-muted: #64748b;--color-border: #e2e8f0;--color-tag-bg: #eff6ff;--color-tag-text: #1d4ed8;--color-error: #dc2626}*{box-sizing:border-box;margin:0;padding:0}body{font-family:-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,sans-serif;background:var(--color-bg);color:var(--color-text);line-height:1.6}.app{max-width:1100px;margin:0 auto;padding:2rem 1rem}header{margin-bottom:2rem}.header-row{display:flex;justify-content:space-between;align-items:flex-start}.mode-toggle{padding:.4rem 1rem;border:1px solid var(--color-border);border-radius:6px;background:var(--color-card);color:var(--color-text);font-size:.85rem;font-weight:500;cursor:pointer;white-space:nowrap}.mode-toggle:hover{background:var(--color-bg)}.mode-toggle.live{border-color:var(--color-primary);color:var(--color-primary)}header h1{font-size:1.75rem;color:var(--color-primary)}header p{color:var(--color-muted)}.status{padding:2rem;text-align:center;color:var(--color-muted)}.status.error{color:var(--color-error)}.demo-layout{display:grid;grid-template-columns:220px 1fr;gap:1.5rem}.filter-panel{background:var(--color-card);border:1px solid var(--color-border);border-radius:8px;padding:1rem;align-self:start;position:sticky;top:1rem}.filter-panel h3{font-size:.9rem;margin-bottom:.5rem}.filter-header{display:flex;justify-content:space-between;align-items:center;margin-bottom:.25rem}.filter-hint{font-size:.8rem;color:var(--color-muted)}.filter-count{font-size:.8rem;color:var(--color-muted);margin-bottom:.75rem}.filter-clear{font-size:.75rem;color:var(--color-primary);background:none;border:none;cursor:pointer;padding:0}.filter-clear:hover{text-decoration:underline}.filter-chip{display:inline-block;padding:.2rem .5rem;border:none;border-radius:4px;font-size:.75rem;font-weight:500;margin:.2rem .2rem .2rem 0;cursor:pointer}.filter-chip:hover{opacity:.7}.chip-condition{background:#fef2f2;color:#991b1b}.chip-procedure{background:#eff6ff;color:#1e40af}.chart-grid{display:grid;grid-template-columns:1fr 1fr;gap:1.5rem}@media(max-width:900px){.demo-layout{grid-template-columns:1fr}}@media(max-width:700px){.chart-grid{grid-template-columns:1fr}}.chart-panel{background:var(--color-card);border:1px solid var(--color-border);border-radius:8px;padding:1.25rem}.chart-panel h3{font-size:1rem;margin-bottom:.5rem;color:var(--color-text)}.study-card{background:var(--color-card);border:1px solid var(--color-border);border-radius:8px;padding:1.5rem;margin-bottom:1.5rem}.study-header{margin-bottom:1.25rem}.study-header h2{font-size:1.25rem;margin-bottom:.25rem}.study-header code{font-size:.85rem;color:var(--color-muted)}.study-header p{margin-top:.5rem;color:var(--color-muted)}.participant-count{display:inline-block;margin-top:.5rem;font-weight:600;color:var(--color-primary)}.tags{display:flex;gap:.4rem;margin-top:.5rem;flex-wrap:wrap}.tag{display:inline-block;padding:.15rem .5rem;background:var(--color-tag-bg);color:var(--color-tag-text);border-radius:4px;font-size:.8rem;font-weight:500}